研究发现饥饿感或能避免大脑认知功能衰退

来源: 生物360 / 作者: koo / 时间: 2013-04-08
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研究发现饥饿感或能避免大脑认知功能衰退

"Stay hungry, stay foolish."

日前,阿拉巴马大学的一项最新研究显示,激素信号是机体空腹与大脑存在饥饿感的“中间者”,对激素的调控也许能够有效地应对与年龄相关的认知下降病症,这种方法与限制热量摄入的治疗手段比较相似。相关论文近日刊登了《PLOS ONE》杂志上。

研究人员表示,这项研究基于老鼠模型,首次揭示出了饥饿能降低阿耳茨海默氏病发病机理。如果其中涉及的机制得到证实,激素饥饿信号也许能开辟出一种新的途径来治疗阿耳茨海默氏病,即可通过单一的方式也可与热量限制结合治疗。

热量限制属于养生疗法,即个体摄入较平均值低的卡路里,但又不致于引发营养失调。对多个物种的研究结果显示,该方法能够保护神经避免出现变性紊乱并且还能延长寿命,但这种效果在人类随机临床实验中还未得到证实。

研究人员推断,饥饿感会造成适度的紧张,反过来就会触发机体的代谢信号通路,从而对抗引发阿耳茨海默氏病的沉积斑块。这是典型的毒物兴奋效应理论,即有害的压力源处于一个适当的水平将对机体有益。

了解更多:

Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model

PLoS ONE, April 2, 2013 | doi:10.1371/journal.pone.0060437

It has been shown that caloric restriction (CR) delays aging and possibly delays the development of Alzheimer's disease (AD). We conjecture that the mechanism may involve interoceptive cues, rather than reduced energy intake per se. We determined that hunger alone, induced by a ghrelin agonist, reduces AD pathology and improves cognition in the APP-SwDI mouse model of AD. Long-term treatment with a ghrelin agonist was sufficient to improve the performance in the water maze. The treatment also reduced levels of amyloid beta (Aβ) and inflammation (microglial activation) at 6 months of age compared to the control group, similar to the effect of CR. Thus, a hunger-inducing drug attenuates AD pathology, in the absence of CR, and the neuroendocrine aspects of hunger also prevent age-related cognitive decline.

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