高彩霞

研究员

一位试图通过改造一些重要的农业植物做出成绩的基因编辑专家。

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近期论文

  1. Zhang D, Xu Z, Cao S, Chen K, Li S, Liu X, Gao C, Zhang B, Zhou Y. An uncanonical CCCH-tandem zinc finger protein represses secondary wall synthesis and controls mechanical strength in rice. Molecular plant. 2017 Nov 21;. doi: 10.1016/j.molp.2017.11.004

  2. Zheng Z, Zuo Z, Zhu P, Wang F, Yin H, Peng X, Fang J, Cui H, Gao C, Song H, Ouyang P, Zhou Y, Zhao S. A study on the expression of apoptotic molecules related to death receptor and endoplasmic reticulum pathways in the jejunum of AFB1-intoxicated chickens. Oncotarget. 2017 Oct 27;8(52):89655-89664. doi: 10.18632/oncotarget.20333

  3. Wang M, Wang S, Liang Z, Shi W, Gao C, Xia G. From Genetic Stock to Genome Editing: Gene Exploitation in Wheat. Trends in biotechnology. 2017 Oct 25;. doi: 10.1016/j.tibtech.2017.10.002

  4. Gu F, Gao C. [Preface for genome editing special issue]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2017 Oct 25;33(10):1661-1664. doi: 10.13345/j.cjb.170374

  5. Zhang D, Zhang H, Li T, Chen K, Qiu JL, Gao C. Perfectly matched 20-nucleotide guide RNA sequences enable robust genome editing using high-fidelity SpCas9 nucleases. Genome biology. 2017 Oct 11;18(1):191. doi: 10.1186/s13059-017-1325-9

  6. Wang C, Liu W, Wang G, Li J, Dong L, Han L, Wang Q, Tian J, Yu Y, Gao C, Kong Z. KTN80 confers precision to microtubule severing by specific targeting of katanin complexes in plant cells. The EMBO journal. 2017 Dec 1;36(23):3435-3447. doi: 10.15252/embj.201796823

  7. Tu M, Lin L, Cheng Y, He X, Sun H, Xie H, Fu J, Liu C, Li J, Chen D, Xi H, Xue D, Liu Q, Zhao J, Gao C, Song Z, Qu J, Gu F. A 'new lease of life': FnCpf1 possesses DNA cleavage activity for genome editing in human cells. Nucleic acids research. 2017 Nov 2;45(19):11295-11304. doi: 10.1093/nar/gkx783

  8. Wang Y, Zong Y, Gao C. Targeted Mutagenesis in Hexaploid Bread Wheat Using the TALEN and CRISPR/Cas Systems. Methods in molecular biology (Clifton, N.J.). 2017;1679:169-185. doi: 10.1007/978-1-4939-7337-8_11

  9. Wang Y, Yu H, Tian C, Sajjad M, Gao C, Tong Y, Wang X, Jiao Y. Transcriptome Association Identifies Regulators of Wheat Spike Architecture. Plant physiology. 2017 Oct;175(2):746-757. doi: 10.1104/pp.17.00694

  10. Yin K, Gao C, Qiu JL. Progress and prospects in plant genome editing. Nature plants. 2017 Jul 31;3:17107. doi: 10.1038/nplants.2017.107

  11. Meng X, Yu H, Zhang Y, Zhuang F, Song X, Gao S, Gao C, Li J. Construction of a Genome-Wide Mutant Library in Rice Using CRISPR/Cas9. Molecular plant. 2017 Sep 12;10(9):1238-1241. doi: 10.1016/j.molp.2017.06.006

  12. Jiao R, Gao C. Anything impossible with CRISPR/Cas9? Science China. Life sciences. 2017 May;60(5):445-446. doi: 10.1007/s11427-017-9069-0

  13. Ran Y, Liang Z, Gao C. Current and future editing reagent delivery systems for plant genome editing. Science China. Life sciences. 2017 May;60(5):490-505. doi: 10.1007/s11427-017-9022-1

  14. Zhang Y, Bai Y, Wu G, Zou S, Chen Y, Gao C, Tang D. Simultaneous modification of three homoeologs of TaEDR1 by genome editing enhances powdery mildew resistance in wheat. The Plant journal : for cell and molecular biology. 2017 Aug;91(4):714-724. doi: 10.1111/tpj.13599

  15. Li J, Zhang H, Si X, Tian Y, Chen K, Liu J, Chen H, Gao C. Generation of thermosensitive male-sterile maize by targeted knockout of the ZmTMS5 gene. Journal of genetics and genomics = Yi chuan xue bao. 2017 Sep 20;44(9):465-468. doi: 10.1016/j.jgg.2017.02.002

  16. Gao C, Quan J, Jiang X, Li C, Lu X, Chen H. Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs. Frontiers in immunology. 2017;8:282. doi: 10.3389/fimmu.2017.00282

  17. Feng W, Wang H, Zhang P, Gao C, Tao J, Ge Z, Zhu D, Bi Y. Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats. Biochimica et biophysica acta. 2017 Jul;1861(7):1801-1812. doi: 10.1016/j.bbagen.2017.03.017

  18. Feng W, Gao C, Bi Y, Wu M, Li P, Shen S, Chen W, Yin T, Zhu D. Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease. Journal of diabetes. 2017 Aug;9(8):800-809. doi: 10.1111/1753-0407.12555

  19. Zong Y, Wang Y, Li C, Zhang R, Chen K, Ran Y, Qiu JL, Wang D, Gao C. Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion. Nature biotechnology. 2017 May;35(5):438-440. doi: 10.1038/nbt.3811

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