朱冰
中科院生物物理所研究员
http://www.bio360.net/attachments/character/2016/12/1482389322a4c60997cd2e35fd.jpg

研究学习经历:

编辑
1992 年浙江大学生物科学与技术系学士, 1995 年中国水稻研究所硕士,1999 年中科院上海植物生理所博士, 1999-2002 年瑞士 Freidrich-Miescher Institute 博士后,2002-2006 年美国 Howard Hughes Medical Institute 博士后。 2006-2014 北京生命科学研究所研究员。 2014- 至今中科院生物物理所研究员。2012-2017 任美国 Howard Hughes Medical Institute 国际青年科学家。主要从事表观遗传信息建立、维持与解读的机制研究。

代表性论文:

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  1. Xiong J, Zhang Z*, Chen J, Huang H, Xu Y, Ding X, Zheng Y, Nishinakamura R, Xu GL, Wang H, Chen S, Gao S, Zhu B*. Cooperative Action Between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine. Mol Cell 2016 (In Press)
  2. Liu N, Zhang Z, Wu H*, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B*. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 2015; 29: 379-393
  3. Yuan G, Ma B, Yuan W, Zhang Z, Chen P, Ding X, Feng L, Shen X, Chen S, Li G, Zhu B*. Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases. J Biol Chem. 2013; 288: 30832-30842
  4. Huang C, Zhang Z, Xu X, Li Y, Li Z, Ma Y, Cai T, Zhu B*. H3.3-H4 tetramer splitting events feature cell-type specific enhancers. Plos Genet. 2013; 9: e1003558
  5. Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S*, Zhu B*. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 Lysine 27 methylation.Science 2012; 337: 971-975
  6. Xu M, Wang W, Chen S*, Zhu B*. A model for mitotic inheritance of histone lysine methylation. EMBO Rep. 2012; 13: 60-67
  7. Chen X, Xiong J, Xu M, Chen S*, Zhu B*. Symmetrical modification within a nucleosome is not required globally for histone lysine methylation. EMBO Rep. 2011; 12: 244-251
  8. Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B*. H3K36 methylation antagonizes PRC2 mediated H3K27 methylation. J Biol Chem. 2011; 286: 7983-7989
  9. Xu M, Long C, Chen X, Huang C, Chen S*, Zhu B*. Partition of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 2010; 328: 94-98

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