慈维敏
中国科学院北京基因组研究所,研究员
http://www.bio360.net/attachments/character/2016/12/148239310866137a3ed48ae006.jpg

研究学习经历:

编辑

1999 年北京师范大学物理学学士,2004 年中国科学院生物物理研究所生物物理学博士,2004 年 -2008 年美国爱因斯坦医学院从事博士后研究,2008 年 -2009 年美国康奈尔医学院从事博士后研究,2009 年 -2014 年 1 月中国科学院北京基因组研究所,副研究员,2014 年至今中国科学院北京基因组研究所,研究员。主要致力于 DNA 甲基化表观遗传调控在胚胎发育和肿瘤发生、发展及转移中的调控功能和分子机制研究,探索表观调控在恶性肿瘤中的作用机制和靶向治疗新策略,同时还关注基因表达调控在正常胚胎发育和细胞分化中的作用研究。近 5 年来,主持多项国家自然科学基金重大集成、培育及面上项目、中国科学院前沿科学重点研究项目等,并获得了 2015 年度自然科学基金优秀青年项目支持,以通讯作者或第一作者身份在 Cell(封面 )、Cancer Cell、Cell Research 以及 Blood 等国际著名学术杂志发表文章数篇。

代表性论文:

编辑
  1. Ke CHEN#, Jing ZHANG#, Zhongqiang GUO#, Qin MA, Zhengzheng XU, Yuanyuan ZHOU, Ziying XU, Zhongwu LI, Yiqiang LIU, Xiongjun YE, Xuesong LI, Bifeng YUAN, Yuwen KE, Chuan HE, Liqun ZHOU*, Jiang LIU*, and Weimin CI*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, 26(1):103-118.

  2. Weimin CI# and Jiang LIU*.Programming and Inheritance of Parental DNA Methylomes in Vertebrates, Physiology, 2015, 30(1): 63– 68.
  3. Lu Wang#, Jun Zhang#, Jialei Duan#, Xinxing Gao#, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu *,Programming and inheritance of parental DNA methylomes in mammals, Cell, 2014, 157(4),979-999.
  4. Guoqiang LI#, Weimin CI#, Subhradip KARMAKAR#, Ke CHEN, Ruby DHAR, Zhixiang FAN, Zhongqiang GUO, Jing ZHANG, Yuwen KE, Lu WANG, Min ZHUANG, Shengdi HU, Xuesong LI, Liqun ZHOU, Xianghong LI, Matthew F. CALABRESE, Edmond R. WATSON, Sandip M. PRASAD, Carrie RINKER-SCHAEFFER, Scott E. EGGENER, Thomas STRICKER, Yong TIAN, Brenda A. SCHULMAN, Jiang LIU*, Kevin P. WHITE*. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer, Cancer Cell, 2014, 25(4):455-468.
  5. Lan JIANG#, Jing ZHANG#, Jing-Jing WANG#, Lu WANG, Li ZHANG, Guoqiang LI, Xiaodan YANG, Xin MA, Xin SUN, Jun CAI, Jun ZHANG, Xingxu HUANG, Miao Yu, Xuegeng WANG, Feng LIU, Chung-I WU, Chuan HE, Bo ZHANG, Weimin CI*, Jiang LIU*. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos, Cell, 2013, 153(4):773-784.
  6. Weimin CI#, Jose M POLO, Leandro CERCHIETTI, Rita SHAKNOVICH, Ling WANG, Shaoning YANG, Kenny YE, Pedro FARINHA, Douglas E. HORSMAN, Randy D. GASCOYNE, Olivier ELEMENTO, Ari MELNICK*. The BCL6 transcriptional program features repression of multiple oncogenes in primary B-cells and is deregulated in DLBCL. Blood, 2009, 113(22):5536-5348.
  7. Jose M POLO#, Weimin CI#, Jonathan D LICHT, Ari MELNICK*, Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B-cells. Blood, 2008, 112(3):644-651.

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