美国斯克利普斯研究所(The Scripps Research Institut

2019-08-26 02:26:52
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名称: 美国斯克利普斯研究所(The Scripps Research Institut

美国斯克利普斯研究所(The Scripps Research Institute (TSRI) www.scripps.edu座落于美国美丽海滨城市圣迭戈的美国斯克利普斯研究所(The Scripps Research Institute (TSRI)一直是位居美国前10名的生物医学研究所,也是美国最大的非赢利性质的研究所,在目前拥有的3000名科学家和员工中,有270位教授,约 800名博士后科研人员和1500名技术辅助科研人员,外加120多名博士生,在美国顶级生命科学研究生教育机构中,它和加州大学旧金山分校,耶鲁大学及 华盛顿大学(圣路易斯)并列第七名。在化学研究生教育机构中,斯克利普斯研究所排名第六名,紧跟在哈佛大学的后面,所以研究水平相当强。斯克利普斯研究所仅为新药开发从各个渠道接受多达8000万美元的研究经费。斯克里普斯研究所The Scripps Research Institute(TSRI),是美国最大的,私立非营利性研究机构,始终站生物医学科学的最前沿。在短短的三个十年,研究所建立了长期的跟踪记录了,并为改善人类的卫生状况作出了重大贡献。

斯克里普斯研究所The Scripps Research Institute(TSRI)已经成为国际上所公认的,其基础研究含盖免疫学,分子和细胞生物学,化学,神经科学,自身免疫性疾病,心血管病学,病毒学和合成疫苗的发展。特别重要的是,在生物分子基本结构和生物分子设计方面,斯克里普斯研究所The Scripps Research Institute(TSRI)是其中极少数世界领先的中心。

斯克里普斯研究所The Scripps Research Institute(TSRI)强调建立基本的认识,在生物科学领域,为应用的医疗和物资的发现;追求基本的科学进步,通过跨学科的项目和合作,以及教育和培训研究人员准备,以满足科技革命的挑战对下一世纪。

斯克利普斯研究所由著名慈善家Ellen Browning Scripps创办于1924年。斯克利普斯研究所创办除期以免疫性疾病为重点。1977年斯克利普斯研究机构拥有临床研究和基础研究两部分,1991年开始临床部分独立出去,成为加州最好的临床医院之一。斯克利普斯研究所从1980年开始招收博士研究生,所以研究所的网址是:www.scripps.edu而不像许多非赢利性的研究所是xxx.org。

斯克利普斯研究所研究阵容十分强大,所里的许多教授和研究员都是大牛级的人物,拥有三位诺贝尔奖级的人物神经学家Gerald Edelman博士,发明核磁共振的生物物理学家Kurt Wuthrich博士和2001年的化学奖获得者Barry Sharpless博士。研究所还拥有19名美国科学院士,16名医学院士和16名科学艺术院士。研究所的研究方向也非常广泛,包括生物医学的各个方面, 但是斯克利普斯研究所以免疫学,化学和实验生物学见长,目前斯克利普斯研究所拥有14个系,8个研究中心(所)跟加州,佛罗里达州两个所区,两所去都座落在美丽的海岸城市,外加宜人的气候,倚丽的南国风光,是很多科学家们心倚的学术殿堂。

研究所的(系科)

肿瘤生物学 Cancer Biology细胞生物学 Cell Biology化学生理学 Chemical Physiology化学 Chemistry神经成瘾性疾病 Committee on the Neurobiology of Addictive Disorders遗传学 Genetics免疫学和微升物学 Immunology and Microbial Science病原学 Infectology分子生物学 Molecular Biology分子和实验医学 Molecular and Experimental Medicine分子和整合神经学 Molecular and Integrative Neurosciences分子治疗学 Molecular Therapeutics神经生物学 Neurobiology科技转化研究所 Translational Research Institute

研究中心和项目

综合分子生物学中心 Center for Integrative Molecular Biosciences (CIMBio)翰锐多然神经研究所 Harold L. Dorris Neurological Research Institute 海伦多然儿童发育神经精神疾病研究所 Helen L. Dorris Child 和 Adolescent Neuro-Psychiatric Disorder Institute儿童期和被忽视的疾病研究所 Institute for Childhood and Neglected Diseases皮尔森酒精和成瘾研究中心 Pearson Center for Alcohol and Addiction Research斯克利普斯应用科学研究所 Scripps Translational Science Institute斯卡格化学生物学研究所 The Skaggs Institute for Chemical Biology医学蠕虫研究所 The Worm Institute for Research and Medicine (WIRM)

斯克利普斯研究所近些年的主要科学研究成果

发现了抑制脑肿瘤血管生长因子和眼科疾病的新血管生长因子;在小鼠上发现了减低核心体温而使寿命竲加20%的分子机制;研发了调控神经退行性疾病像福氏共济失调症的药物;研制出了抗肥胖疫苗;在干细胞研究方面发现了控制胚胎干细胞命运的小分子合成物,使干细胞能够转化成为心肌细胞,为心脏再生提供了新的制疗前景。特别一提的是研发出一种全新的制备疾病作战蛋白的方法,这种制疗性单克隆抗体的功效比经典的药效提高了上千倍,等等。。。

斯克利普斯研究所的成功之处很值得深思,从一个60年代还是个默默无闻的小研究所如今变成了全美最大的生命科学研究所,并集临床,教学(培养博士和训练博士后),再到2011年即将开学的Scripps 医学院, 第一次在美国引入了以硕士学位为起点的医学院学生教育体制,必将在美国的高质量医生培养上独树一旗,写下历史的记录。

斯克利普斯研究所地处美国东西两岸最美的海滨城市-圣迭戈和佛洛里达州的舟皮特市(Jupiter,位于佛州最美的海岸棕榈树县),怡人的气候,美丽的城市自然是吸人科技人才的有利因素,良好的科研环境更是科技发达的必要条件,在南加州圣迭戈市的所区旁边,还拥有著名的加州大学圣迭戈分校(UCSD)和索克(Salk)生物科学研究所,这些科研院校都是60年代后开始高速发展起来的,他们和Scripps一起,将南加州的生命科学带领到美国的前沿,今天的圣迭戈是已是全美5大生物高科技科技园区之一,除 Scripps, UCSD和Salk这些科研机构外,还有200家生物科技公司。作为圣迭戈最有名的研究所Scripps研究所今后的科研会更上一层楼的。About TSRI

Introduction

The Scripps Research Institute, one of the country's largest, private, non-profit research organizations, has always stood at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. In just three decades the Institute has established a lengthy track record of major contributions to the betterment of health and the human condition.

The Institute has become internationally recognized for its basic research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune diseases, cardiovascular diseases, virology and synthetic vaccine development. Particularly significant is the Institute's study of the basic structure and design of biological molecules; in this arena TSRI is among a handful of the world's leading centers.

The philosophy of The Scripps Research Institute emphasizes the creation of basic knowledge in the biosciences for the application of medical and material discoveries; the pursuit of fundamental scientific advances through interdisciplinary programs and collaborations, and the education and training of researchers preparing to meet the scientific challenges of the next century.

The bulk of the Institute's funding is derived from the National Institutes of Health and other federal agencies. In today's environment of increasing competition for shrinking federal dollars, however, collaborative industrial partnerships with leading pharmaceutical companies provide additional funding in several areas key to the organization's research objectives.

Scripps Research's facilities are located in La Jolla, California, and Jupiter, Florida. In La Jolla, Scripps Research operates more than 1 million square feet of laboratory space. The campus spans approximately 35 acres of land of which 14.7 are owned by the institute. Located in close proximity to the University of California, San Diego, the campus is situated with easy access to San Diego's scientific community, which includes The Salk Institute and the Burnham Institute, as well as a concentration of some 300 biotechnology companies. In Jupiter, Scripps Research operates a 350,000-square-foot facility consisting of three buildings completed in early 2009. Adjacent to Florida Atlantic University and the future home of a branch of the Max Plank Institute, the new Scripps Florida campus is already becoming the focus of an emerging cluster of biotechnology and pharmaceutical firms that will serve as an economic engine for the region.

The Institute enjoys one of the world's leading private computational facilities with an array of computers, including LINUX high-performance computing clusters. Research is further supported by X-ray crystallography laboratories, high performance NMR spectrometry including a state-of-the-art 900 MHz instrument, electron microscopy, optical spectroscopy, a DNA sequencing laboratory and a fluorescence activated cell sorting facility. The centerpiece technology at Scripps Florida is a $10 million high throughput screening robotics system, which is used by researchers on both campuses and shared by research institutions throughout the State of Florida.

Rather than isolating faculty members and laboratories into separate and distinct disciplines, as is generally the prescribed university model, the cooperative, collaborative spirit is encouraged and embraced. While the level of scientific investigation is intense, the atmosphere is collegial, relaxed and informal. Technicians, postdoctoral fellows and administrative support staff all are considered part of the team and are given the latitude and responsibility to accomplish their tasks so as to serve the best interests of science. The pursuit of scientific excellence is paramount and all efforts are directed toward that end.

TSRI's adherence to the highest scientific standards, emphasis on a multidisciplinary approach to problem solving, philosophy toward the perpetuation of knowledge through education and reputation for research excellence provide an unparalleled scientific environment.

History

While its roots go back to the founding of the Scripps Metabolic Clinic in 1924 by philanthropist Ellen Browning Scripps, The Scripps Research Institute's modern beginnings date to the 1946 establishment of Scripps Clinic and Research Foundation, when a major portion of the Clinic's limited reserves were committed to the construction of a new research facility and to the recruitment of top biomedical scientists.

In 1961, the institution recruited pioneering immunologist Frank Dixon and four of his colleagues from the University of Pittsburgh, researchers who were then contributing insightful observations on the causes and progression of autoimmune disease, to establish a Department of Experimental Pathology in La Jolla.

Their work attracted others and the research program flourished and persified into biochemistry and microbiology, virology, studies of blood coagulation, and cancer research. From the outset, the guiding philosophy was clinical and basic investigations of the pathogenesis of human disease.

In 1977 the multiple research programs that had developed were formally drawn together into the Research Institute of Scripps Clinic, as it had come to be named, and by the mid-1980s laboratory space had grown to some 300,000 square feet. Major programs in cell and molecular biology and synthetic and bioorganic chemistry had developed, in addition to efforts in immunology and clinically oriented investigations. The Department of Neurobiology was established at the Institute in the 1992.

As the faculty roster has grown, so naturally has the focus and number of areas of research. Today, TSRI scientists are actively investigating biological and chemical aspects of more than 40 diseases, including AIDS, alcoholism, allergy, Alzheimer's disease, cancer, dementia, depression, diabetes, genetic diseases, hepatitis, infectious diseases, multiple sclerosis, renal disease, scleroderma, Sjogren's syndrome, sleep disorders, and diseases involving neural and muscular degeneration.

Among other areas of research that cross specific disease lines are those that involve numerous investigations into the structure and function of proteins; biocatalysis and protein design; the factors, processes and regulation of inflammation; and the form and working of animal and plant cells. All in all, the quality, scope and depth of the science conducted at the Institute enable it to be ranked among the finest scientific research organizations in the world.

In 1991, when Scripps Clinic and Research Foundation and Scripps Memorial Hospitals reaffiliated, the Research Institute became a separate corporation under the parent organization, Scripps Institutions of Medicine and Science. With that change its name became The Scripps Research Institute, a name that will likely be associated with some of the greatest biomedical advances of the decades ahead.

In late 2003, The Scripps Research Institute took a dramatic step in announcing the establishment of a major science center in Palm Beach County, Florida, focusing on biomedical research, technology development and drug design. Funding for the new campus and initial staffing is being supported by the State of Florida via economic development funds as well as local government. Months of intensive discussions with Florida Governor Jeb Bush and state and local officials culminated in the large scale agreement between Scripps Research and the State of Florida. The synergy between the faculties and research conducted at both facilities is expected to lead to significant new developments to improve human health.